Searchable abstracts of presentations at key conferences in endocrinology

ea0026p188 | Neuroendocrinology | ECE2011

Glucocorticoid receptor gene polymorphisms are associated with disease course during pregnancy and the post-partum period in rheumatoid arthritis

Quax R A M , de Man Y A , Koper J W , Willemsen S P , Lamberts S W J , Hazes J M W , Dolhain R J E M , Feelders R A

Background: The mechanism underlying the spontaneous improvement of rheumatoid arthritis (RA) during pregnancy and the subsequent post-partum flare is incompletely understood. The glucocorticoid receptor (GR) polymorphisms Bcl1 and 9β are associated with an increased and decreased glucocorticoid sensitivity respectively. We examined the relation between carriership of these functional GR polymorphisms and disease course during pregnancy and post-partum in RA...

ea0026p351 | Steroid metabolism | ECE2011

Evaluation of a method to measure long term cortisol levels in health and disease

Manenschijn L , Koper J W , van den Akker E L T , Feelders R A , Lamberts S W J , van Rossum E F C

Introduction: Elevated levels of cortisol are known to induce a wide range of pathology, e.g. abdominal obesity, type 2 diabetes and cardiovascular disease. Measuring serum and saliva cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels and might reflect cortisol exposure in patients with hyper- or hypo-cortisolism and in healthy persons. Our aims were to explore this measurement of cor...

ea0026p196 | Pituitary | ECE2011

Coping strategies in patients after treatment for functioning or non-functioning pituitary adenomas

Tiemensma J , Kaptein A A , Pereira A M , Smit J W A , Romijn J A , Biermasz N R

Context and objective: Coping strategies may affect quality of life (QoL), which is decreased in patients after treatment for Cushing’s disease, acromegaly, or non-functioning macroadenomas (NFMA). We aimed to explore coping strategies in these patients, since this has never been done before.Design: A cross sectional study.Subjects: We included patients treated for Cushing’s disease (n=42), for acromegaly (n...

ea0026p215 | Pituitary | ECE2011

Illness perceptions, quality of life and self-reported physical symptoms in patients after long-term remission of Cushing’s syndrome

Tiemensma J , Kaptein A A , Pereira A M , Smit J W A , Romijn J A , Biermasz N R

Context and objective: Illness perceptions pertain the pattern of beliefs patients develop about their illness. These views are determinants of behavior directed at the illness. Illness perceptions are determinants of quality of life (QoL). QoL remains impaired in patients after treatment of endogenous hypercortisolism, however, illness perceptions were never studied in these patients. The objective of the current study was to explore illness perceptions and its relation with ...

ea0026p233 | Pituitary | ECE2011

GH replacement therapy in elderly GH deficient patients: a systematic review

Kokshoorn N E , Biermasz N R , Roelfsema F , Smit J W A , Pereira A M , Romijn J A

Context: Recombinant human GH (rhGH) is indicated for the treatment of adult subjects with GH deficiency (GHD). However, conflicting data are available on the efficacy of rhGH treatment in elderly GHD patients.Objective: To assess the efficacy of rhGH treatment in elderly GHD subjects.Methods: We searched PubMed, Cochrane Library, Web of Science, and EMBASE.Study selection: Eligible studies included GHD patie...

ea0077op2.2 | Adrenal and Cardiovascular | SFEBES2021

Single-centre analysis of 900 short synacthen tests: do pre-test clinical or biochemical variables predict failure?

Dilrukshi M D S A , Beck K J , Loo H , May C , Jafar-Mohammadi B , Pofi R , Tomlinson J W , Pal A

Short synacthen test (SST) is the most widely used dynamic test of hypothalamic-pituitary-adrenal (HPA) axis function. It’s simple to conduct but requires nursing time and is relatively costly given 15-fold price increase in synacthen since 2015. We audited our SST use with the aim of reviewing clinical indications for testing and identifying useful predictors of test outcome. Baseline referral, clinical and biochemical data were retrospectively collected for individuals ...

ea0026p134 | Growth factors | ECE2011

Circulating insulin-like growth factor 1 (IGF1) and mortality: meta-analysis and dose-response meta-regression

Burgers A M G , Biermasz N R , Schoones J W , Pereira A M , Renehan A G , Zwahlen M , Egger M , Dekkers O M

Background: Insulin-like growth factor 1 (IGF1) plays a central role in metabolism and growth regulation. High IGF1 levels are associated with an increased risk of cancer, low IGF1 levels with increased risk for cardiovascular disease. We hypothesized that the relationship between circulating total IGF1 levels and mortality is U-shaped.Methods: We performed a systematic review searching PubMed, EMBASE, Web of Science, Cochrane Library (1985 to September ...

ea0026p256 | Pituitary | ECE2011

Low incidence of adrenal insufficiency after transsphenoidal surgery in patients with acromegaly: a long-term follow-up study

Burgers A M G , Kokshoorn N E , Pereira A M , Roelfsema F , Smit J W A , Biermasz N R , Romijn J A

Background: The long-term prevalence of adrenal insufficiency after transsphenoidal surgery for GH secreting pituitary adenomas was unknown. However, recently a single study reported a high prevalence of adrenal insufficiency after surgical and/or medical treatment without postoperative radiotherapy in acromegalic patients.Aim: To assess the prevalence and incidence rate of adrenal insufficiency in consecutive patients during long-term follow-up after su...

ea0073oc12.4 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Improvements in long-term appetite-regulating hormones in response to a combined lifestyle intervention for obesity

Kuckuck Susanne , van der Valk Eline S. , Scheurink Anton J. W. , van den Berg Sjoerd A. A. , van Rossum Elisabeth F. C.

IntroductionAltered levels of hormonal appetite regulators have been observed in obesity (BMI ≥ 30.0 kg/m2), most prominently increases of insulin and leptin (indicating resistance) as well as decreases of adiponectin–all of which are long-term energy regulators and adiposity signals. Disrupted signaling of these hormones may have detrimental effects on metabolism, but may also promote weight gain. Weight loss is often accompanied ...

ea0037ep94 | Adrenal cortex | ECE2015

Combined effects of sirolimus and mitotane in the inhibition of growth in human adrenocortical carcinoma cells

De Martino Maria Cristina , van Koetsveld Peter M , Feeldes Richard A , Lamberts Steven W J , de Herder Wouter W , Colao Annamaria , Pivonello Rosario , Hofland Leo J

Adrenocortical cancer (ACC) is a rare cancer with poor prognosis and scant treatment options. Mitotane alone, or in combination with cytotoxic chemotherapy, represents the referral current treatment for patients with unresectable ACC. Recent studies have shown that mTOR inhibitors suppress growth of ACC cells. This study aimed at evaluating the effects of mitotane in combination with mTOR inhibitors. In H295 and SW13 cells we tested the effects of a 6 day treatment with increa...